Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells
摘要：
The mechanism by which erythropoietin controls mammalian erythrocyte production is unknown. Labeling experiments in vitro with [$^3$H]thymidine demonstrated DNA cleavage in erythroid progenitor cells that was accompanied by DNA repair and synthesis. Erythropoietin reduced DNA cleavage by a factor of 2.6. In the absence of erythropoietin, erythroid progenitor cells accumulated DNA cleavage fragments characteristic of those found in programmed cell death (apoptosis) by 2 to 4 hours and began dying by 16 hours. In the presence of erythropoietin, the progenitor cells survived and differentiated into reticulocytes. Thus, apoptosis is a major component of normal erythropoiesis, and erythropoietin controls erythrocyte production by retarding DNA breakdown and preventing apoptosis in erythroid progenitor cells.
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关键词：
basic biological sciences dna cleavage erythropoietin biological functions cell differentiation dna repair dna replication inhibition mice
DOI：
10.1126/science.2326648
被引量：
年份：
1990
Wiley
万方医学
NCBI
NCBI
Europe PMC
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