The leukocyte common antigen, CD45 and other protein tyrosine phosphatases in hematopoietic cells
摘要：
Numerous protein tyrosine phosphatases have been characterized that are expressed by hematopoietic-derived cells. CD45, a transmembrane protein tyrosine phosphatase expressed by all nucleated cells of hematopoietic origin, has been a prototype for studying the function of these enzymes. In T lymphocytes, CD45 serves to dephosphorylate and activate members of the Src-tyrosine kinase family. Without CD45 function, T cells cannot respond to antigen. Therefore, CD45 functions positively to regulate lymphocyte activation. The characteristics of other protein tyrosine phosphatases found in hematopoietic-derived cells suggests that they are also essential in regulating cell differentiation and activation.
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关键词：
Animals Humans T-Lymphocytes Hematopoietic Stem Cells Receptors, Antigen, T-Cell Signal Transduction Substrate Specificity Protein-Tyrosine Kinases Protein Tyrosine Phosphatases Antigens, CD45
DOI：
10.1006/scel.1993.1049
被引量：
年份：
1993
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