Sensing and reacting to microbes through the inflammasomes
摘要：
Inflammasomes are multiprotein complexes that activate caspase-1, which leads to maturation of the proinflammatory cytokines interleukin 1 (IL-1) and IL-18 and the induction of pyroptosis. Members of the Nod-like receptor (NLR) family, including NLRP1, NLRP3 and NLRC4, and the cytosolic receptor AIM2 are critical components of inflammasomes and link microbial and endogenous danger signals to the activation of caspase-1. In response to microbial infection, activation of the inflammasomes contributes to host protection by inducing immune responses that limit microbial invasion, but deregulated activation of inflammasomes is associated with autoinflammatory syndromes and other pathologies. Thus, understanding inflammasome pathways may provide insight into the mechanisms of host defense against microbes and the development of inflammatory disorders.
展开
DOI：
10.1038/ni.2231
被引量：
年份：
2012
Nature
Nature
(全网免费下载)
国家科技图书文献中心
(权威机构)
EBSCO
Semantic Scholar
查看更多
Semantic Scholar
(全网免费下载)
dx.doi.org
Ingenta
NCBI
Europe PMC
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
NCBI
ProQuest
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
EBSCO
ufjf.br
(全网免费下载)
science-open.com
学术范
(全网免费下载)
embomolmed.embopress.org
ftp.palgrave-journals.com
intl-mbio.asm.org
bvsalud.org
readcube.com
cshperspectives.cshlp.org
ajpheart.physiology.org
rstb.royalsocietypublishing.org
mendeley.com
pubget.com
pubfacts.com
onAcademic
www.socolar.com
学术范
钛学术
钛学术
(全网免费下载)
Nature
(全网免费下载)
Semantic Scholar
(全网免费下载)
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
ResearchGate
(全网免费下载)
ufjf.br
(全网免费下载)
钛学术
(全网免费下载)
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
