摘要：

The tertiary amines of the formula ##STR1## wherein n represents a whole number of 1 to 5;X.sup.1 represents phenyl or phenyl mono-, di- or tri-substituted by R.sup.1, R.sup.2 and R. sup.3 ;< P>X.sup.2 represents hydrogen, lower-alkyl, phenyl or phenyl mono-, di- or tri-substituted by R.sup.1, R.sup.2 and R. sup.3 ; Y represents hydrogen, lower-alkyl, hydroxymethyl, carboxy or lower-alkoxycarbonyl;Z represents a group of the formula ##STR2## R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, halogen, hydroxy, benzyloxy, lower-alkyl, lower- alkoxy, hydroxymethyl, amino, acylamino, lower-alkoxybenzylamino, nitro, carbamoyl, trifluoromethyl or lower-alkylsulphonylmethyl;< P>R.sup.4, R.sup.5 and R.sup. 51 represent hydrogen, lower-alkyl, lower-alkoxy, lower alkanoyl, carboxy, cyano, hydroxy, hydroxy-lower- alkyl, acyloxy or a group --C(R.sup.6)&boxH; C(R.sup.7)COOR.sup.8, --SO. sub.2 R.sup.9, --C(O)R.sup.9 or --CH.sub.2 R. sup.10, with the proviso that R.sup.4 does not represent hydrogen when R. sup.5 represents hydroxy, lower-alkyl or lower-alkoxy;R. sup.6, R.sup.7 and R. sup.8 represent hydrogen or lower-alkyl;< P>R.sup.9 represents amino, mono-lower-alkylamino or a group R;< P>R represents di-lower-alkylamino, piperidino, morpholino, thiamorpholino, piperazino or the ether group of a lower aliphatic, cycloaliphatic or araliphatic alcohol or of a phenol; and< P>R.sup.10 represents a group R and, where R.sup.1, R.sup.2 and R.sup. 3 represent hydrogen, halogen, hydroxy, benzyloxy, lower-alkyl, lower- alkoxy, hydroxymethyl, amino, lower-alkoxybenzylamino or trifluoromethyl and simultaneously Y represents hydrogen, lower-alkyl or hydroxymethyl, R. sup.10 can also represent amino or mono-lower-alkylamino,< P>have hypoglycaemic activity and reduce glycosuria. They are manufactured from corresponding primary or secondary amines.

展开