Signalling through phosphoinositide 3-kinases: The lipids take centre stage
摘要：
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids at the 3′ position of the inositol ring to generate the 3-phosphoinositides PI(3)P, PI(3,4)P2 and PI(3,4,5)P3. Recent research has shown that one way in which these lipids function in signal transduction and membrane trafficking is by interacting with 3-phosphoinositide-binding modules in a broad variety of proteins. Specifically, certain FYVE domains bind PI(3)P whereas certain pleckstrin homology domains bind PI(3,4)P2 and/or PI(3,4,5)P3. Also in 1998, PTEN — a major tumour suppressor in human cancer — was also shown to antagonise PI3K signalling by removing the 3-phosphate from 3-phosphoinositides.
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关键词：
Animals Humans GTP-Binding Proteins Phosphoric Monoester Hydrolases Isoenzymes Membrane Lipids Phosphatidylinositols Blood Proteins Neoplasm Proteins Tumor Suppressor Proteins
DOI：
10.1016/S0955-0674(99)80029-5
被引量：
年份：
1999
Elsevier
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