Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
摘要：
The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease. These cells could in turn be used for disease modeling, drug discovery, and eventually autologous cell replacement therapies. Although recent studies have demonstrated the reprogramming of human fibroblasts to a pluripotent state, it remains unclear whether these induced pluripotent stem (iPS) cells can be produced directly from elderly patients with chronic disease. We have generated iPS cells from an 82-year-old woman diagnosed with a familial form of amyotrophic lateral sclerosis (ALS). These patient-specific iPS cells possess properties of embryonic stem cells and were successfully directed to differentiate into motor neurons, the cell type destroyed in ALS.
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关键词：
Humans Spinal Cord Neuroglia Motor Neurons Fibroblasts Pluripotent Stem Cells Cell Line Superoxide Dismutase Transcription Factors Cell Differentiation
DOI：
10.1126/science.1158799
被引量：
Taylor & Francis
国家科技图书文献中心
(权威机构)
Wiley
Semantic Scholar
万方医学
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