摘要：

Activity against the experimental malarias caused by Plasmodium berghei in mice and P. gallinaceum in chicks has been demonstrated for several 2,4,7-triarnino-6-ortho-substituted arylpteridines. The o-methyl and o-chloro derivatives were the most active compounds in the systems examined. A toxicity study in rats and dogs revealed that 2,4,7-triamino-6-o-tolylpteridine is sufficiently nontoxic to be administered in effective doses to humans.

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