Meaningful relationships: the regulation of the Ras\/Raf\/MEK\/ERK pathway by protein interactions
摘要：
The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-regulated kinase) pathway is at the heart of signalling networks that govern proliferation, differentiation and cell survival. Although the basic regulatory steps have been elucidated, many features of this pathway are only beginning to emerge. This review focuses on the role of protein-protein interactions in the regulation of this pathway, and how they contribute to co-ordinate activation steps, subcellular redistribution, substrate phosphorylation and cross-talk with other signalling pathways.
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关键词：
Animals Cytosol Cell Membrane ras Proteins Proto-Oncogene Proteins c-raf Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Signal Transduction Protein Binding Sequence Homology, Amino Acid
DOI：
10.1042/0264-6021:3510289
被引量：
年份：
2000
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