Regulated necrosis: the expanding network of non-apoptotic cell death pathways
摘要：
Cell death research was revitalized by the understanding that necrosis can occur in a highly regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein kinase 1)- and RIPK3-MLKL (mixed lineage kinase domain-like)-mediated necroptosis is the most understood form of regulated necrosis, other examples of this process are emerging, including cell death mechanisms known as parthanatos, oxytosis, ferroptosis, NETosis, pyronecrosis and pyroptosis. Elucidating how these pathways of regulated necrosis are interconnected at the molecular level should enable this process to be therapeutically targeted.
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关键词：
Humans Necrosis Protein Kinases Signal Transduction Apoptosis Receptor-Interacting Protein Serine-Threonine Kinases Cell Death Molecular Targeted Therapy
DOI：
10.1038/nrm3737
被引量：
年份：
2014
Nature
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