摘要：

In recent years, the field of Phosphodiesterase Type 5 (PDE5) inhibitors has reached a state of maturity. Standard issues in medicinal chemistry, such as potency, selectivity, physico-chemical properties and oral bioavailability, have been successfully addressed with the known PDE5 inhibitors. The discovery of further PDE subtypes and the need for specific drug tissue distribution patterns result in a further increase in the knowledge of this PDE inhibitor class. In addition, knowledge gained in different kinase inhibitor classes is fruitful for PDE inhibitors and vice versa. As a plethora of PDEs are already known and new subtypes are still being discovered, scientists in the PDE5 inhibitor field are constantly challenged to continue the search for either more selective inhibitors, compounds with a specifically desirable combination of different PDE inhibitory properties, or compounds demonstrating a very specific tissue distribution.

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