摘要：

Purpose - "Spice" productsreyntheticannabimimetics (SC;lsoalled "syntheticannabinoids")-based designer drugsseds legallternativeoannabisorheir verytrongetrahydrocannabinol (THQ-like effects.he purposefhis paper iso providennalysisforeecentlinicalnd pharmacology/oxicobgyindingselatingoCnd describeowheyould impactnealth, with particularocusnentalealth. Design/methodology/approach -ystematicearchnd descriptivenalysisfhevailable evidencen psychopathological issueselatedoisuse was performedere, whilstaking intoccounthe Pubmed/Medline databases,angefonference proceedingsnd national/internationalgencies'eports.indings - WhileHC is partialgonist,Creullgonistsnheannabinoideceptors (CB-rs)ndhedministrationfultipleCan producedditivend/orynergisticgonistic interaction effectsnhe endocannabinoidystem.hese levelsftrongB-rs'ctivationayeigh enougho produceevere physiologicalnd psychological disturbances.hevailable evidenceuggestsn existingelationshipetweenCsend psychosis ("Spiceophrenia").hecuteC intoxication issuallyharacterizedyachycardia/hypertension; visual/auditoryallucinations;ydriasis;gitation/anxiety;achypnoea; nausea/ vomiting;ndeizures.esearch limitations/implications -hebsenceflinicalrialsnd longitudinaltudies,ogether withheeterogeneityfCompounds does notacilitate precisessessmentfheealthiskselatedoheirse, with long-term effectseingf particularoncern.riginality/value -ppropriate, non-judgemental, preventionampaigns withpecialocusnhe differencesetweenCndannabisay needoerganizedn largecale.theameime,linicians needoeegularlypdatedbout novel psychoactiveubstances, includingC,o promptlyecognizeigns/symptomsf intoxication.

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