Regulation of pancreatic -cell growth and survival by the serine/threonine protein kinase Akt1/PKB

来自 Semantic Scholar

喜欢 0

阅读量：

204

作者：

RL Tuttle，NS Gill，W Pugh，JP Lee，MJ Birnbaum

展开

摘要：

The physiological performance of an organ depends on an interplay between changes in cellular function and organ size, determined by cell growth, proliferation and death. Nowhere is this more evident than in the endocrine pancreas, where disturbances in function or mass result in severe disease. Recently, the insulin signal-transduction pathway has been implicated in both the regulation of hormone secretion from beta cells in mammals as well as the determination of cell and organ size in Drosophila melanogaster. A prominent mediator of the actions of insulin and insulin-like growth factor 1 (IGF-1) is the 3'-phosphoinositide-dependent protein kinase Akt, also known as protein kinase B (PKB). Here we report that overexpression of active Akt1 in the mouse beta cell substantially affects compartment size and function. There was a significant increase in both beta-cell size and total islet mass, accompanied by improved glucose tolerance and complete resistance to experimental diabetes.

展开

关键词：

Islets of Langerhans Animals Mice, Inbred C57BL Mice, Transgenic Mice Rats Diabetes Mellitus, Type 2 Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Cell Division