Injectable Lipid Emulsions—Advancements, Opportunities and Challenges

Injectable lipid emulsions, for decades, have been clinically used as an energy source for hospitalized patients by providing essential fatty acids and vit...

K Hippalgaonkar，S Majumdar，V Kansara - 《Aaps Pharmscitech》

Injectable nanocarriers for biodetoxification

Hospitals routinely treat patients suffering from overdoses of drugs or other toxic chemicals as a result of illicit drug consumption, or accidental exposu...

Leroux，Jean-Christophe - 《Nature Nanotechnology》

Effect of poly(N-vinyl-pyrrolidone)-block-poly(D,L-lactide) as coating agent on the opsonization, phagocytosis, and pharmacokinetics of biodegradable nanop...

The effect of the coating polymer poly(N-vinyl-pyrrolidone) (PVP) on the protein adsorption, phagocytosis, and pharmacokinetics of poly(D,L-lactide)-based ...

G Gaucher，K Asahina，J Wang，... - 《Biomacromolecules》

Liposomes encapsulating beta‐carotene produced by the proliposomes method: characterisation and shelf life of powders and phospholipid vesicles

The objective of this study was to investigate the feasibility of producing proliposomes incorporating beta-carotene by spray drying and to assess the capa...

M Moraes，JMP Carvalho，CR Silva，... - 《International Journal of Food Science & Technology》

Preparation and characterization of highly stable lipid nanoparticles with amorphous core of tuneable viscosity

Lipid nanoparticles (LNP) have been designed based on low cost and human-use approved excipients, and manufactured by an easy, robust, and up-scalable proc...

T Delmas，AC Couffin，PA Bayle，... - 《Journal of Colloid & Interface Science》

Effect of Poly(N-vinyl-pyrrolidone)-block-poly(d,l-lactide) as Coating Agent on the Opsonization, Phagocyto...

The effect of the coating polymer poly(N-vinyl-pyrrolidone) (PVP) on the protein adsorption, phagocytosis, and pharmacokinetics of poly(D,L-lactide)-based ...

Geneviève，Gaucher，Kinji，... - 《Macromolecules》

Effects of Monoglycerides on Rhodamine 123 Accumulation, Estradiol 17 β-D-Glucuronide Bidirectional Transport and MRP2 Protein Expression within Caco-2 cells

Oral drug development had been hindered by the bioavailability issue despite vast market popularity. Lipid excipients had shown to enhance bioavailability of a number of reformulated hydrophobic oral drugs, yet the underlying mechanisms ...

JX Jia，KM Wasan - Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques

The Influence of Surfactant HLB and Oil/Surfactant Ratio on the Formation and Properties of Self-emulsifying Pellets and Microemulsion Reconstitution

鈥揅) was the oil and Cremophor ELP and RH grades and Solutol the surfactants. Pellets were prepared by extrusion/spheronization using microemulsions with ...

I Matsaridou，P Barmpalexis，A Salis，... - 《Aaps Pharmscitech》

Self-Emulsifying Drug Delivery Systems: A Review

Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble or lipophilic drugs. Following their oral administration, these systems rapidly disperse in gastroint...

J Reza - 《International Journal of Pharmaceutical & Life Sciences》

SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES

This invention relates to novel substituted dioxopiperidinyl phthalimide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein: each W is independently selected from hydrogen or deuterium; each Z is independen...

LIU, Julie, F.，TUNG, Roger, D. - US