Ketamine inhibits LPS-induced tumour necrosis factor-alpha and interleukin-6 in an equine macrophage cell line
摘要：
Ketamine is widely used in equine anaesthesia. Beside its anaesthetic and analgesic properties, ketamine possesses a cytokine-modulating activity. However, to date, no data are available regarding the inhibitory effect of ketamine on the cytokine response in horses. In horses, cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) play a pivotal role in the pathogenesis of equine endotoxaemia following gastrointestinal disorders. Hence, the objective of this study was to assess the influence of ketamine on LPS-induced TNF-alpha and IL-6 formation in an equine macrophage cell line (eCAS cells). The results demonstrate a cytokine-modulating activity of ketamine in an equine cell line, suggesting a beneficial role for ketamine in the treatment of equine endotoxaemia.
展开
关键词：
Animals Humans Macrophages Cell Line Ketamine Anesthetics, Dissociative Tumor Necrosis Factor-alpha Horses Lipopolysaccharides Interleukin-6
DOI：
10.1051/vetres:2004061
被引量：
年份：
2005
国家科技图书文献中心
(权威机构)
Wiley
Semantic Scholar
掌桥科研
dx.doi.org
查看更多
Europe PMC
NCBI
NCBI
Oxford Univ Press
ResearchGate
(全网免费下载)
ProQuest
ResearchGate
core.ac.uk
hal.archives-ouvertes.fr
(全网免费下载)
vetres.org
hal.univ-lille3.fr
钛学术
(全网免费下载)
pubfacts.com
publications.edpsciences.org
钛学术
vetres.org
(全网免费下载)
BioMed Central
(全网免费下载)
hal.archives-ouvertes.fr
ResearchGate
(全网免费下载)
hal.archives-ouvertes.fr
(全网免费下载)
vetres.org
(全网免费下载)
BioMed Central
(全网免费下载)
钛学术
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
