Genetically Modified Organisms for Increased Microbial Production of 3-Hydroxypropionic Acid Involving an Oxaloacetate alpha-decarboxylase

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16

申请(专利)号:

US20100891760

申请日期:

2010-09-27

公开/公告号:

US8809027B1

公开/公告日期:

2014-08-19

申请(专利权)人:

MICHAEL D LYNCH;CHRISTOPHER P. MERCOGLIANO

发明人:

Michael D. LynchCP Mercogliano

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摘要:

Microorganism compositions are described that comprise combinations of genetic modifications that include a genetic modification to increase oxaloacetate alpha-decarboxylase enzymatic activity. By such genetic modification a 3-hydroxypropionic acid ("3-HP") production pathway is provided or improved. In various embodiments, comprising other genetic modifications, including selected gene disruptions, 3-HP production is greater than in a control microorganism lacking such combinations of genetic modifications

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