The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex.

来自 dx.doi.org

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阅读量：

107

作者：

V Cavalli，F Vilbois，M Corti，MJ Marcote，K Tamura，M Karin，S Arkinstall，J Gruenberg

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摘要：

Early endocytic membrane traffic is regulated by the small GTPase Rab5, which cycles between GTP- and GDP-bound states as well as between membrane and cytosol. The latter cycle depends on GDI, which functions as a Rab vehicle in the aqueous environment of the cytosol. Here, we report that formation of the GDI:Rab5 complex is stimulated by a cytosolic factor that we purified and then identified as p38 MAPK. We find that p38 regulates GDI in the cytosolic cycle of Rab5 and modulates endocytosis in vivo. Our observations reveal the existence of a cross-talk between endocytosis and the p38-dependent stress response, thus providing molecular evidence that endocytosis can be regulated by the environment.

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关键词：

non-syndromic recessive deafness connexin 26 gene 35delG mutation PCR mutation-specific primers DNA diagnostics test dried blood spots carrier frequency in neonates

DOI：

10.1016/S1097-2765(01)00189-7

被引量：

532

年份：

2001