Polymeric shells for medical imaging prepared from synthetic polymers, and methods for the use thereof
申请(专利)号：
US19950486268
申请日期：
1995-06-06
公开/公告号：
US5512268A
公开/公告日期：
1996-04-30
申请(专利权)人：
VIVORX PHARMACEUTICALS, INC.
被引量：
摘要：
In accordance with the present invention, compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
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