Regulation of protein kinases; controlling activity through activation segment conformation.
摘要：
There are currently at least forty-six unique protein kinase crystal structures, twenty-four of which are available in an active state. Here we examine these structures using a structural bioinformatics approach to understand how the conformation of the activation segment controls kinase activity. Copyright 2004 Cell Press
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关键词：
Animals Humans Protein Kinases Computational Biology Amino Acid Motifs Catalytic Domain Molecular Conformation Protein Structure, Tertiary Sequence Homology, Amino Acid Structure-Activity Relationship
DOI：
10.1016/j.molcel.2004.08.024
被引量：
年份：
2004
Elsevier
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