Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways.
摘要：
Presentation of antigen in the form of immune complexes to B lymphocytes by follicular dendritic cells (FDC) is considered to be a central step in the generation of memory B cells. During this process, which takes place in the microenvironment of the germinal center, B cells and FDC are in close physical contact. In the present study, we have explored the molecular basis of FDC-B cell interaction by using FDC and B cells derived from human tonsils. We found that FDC express high levels of the adhesion receptors intercellular adhesion molecule 1 (ICAM-1 [CD54]) and vascular cell adhesion molecule 1 (VCAM-1), while the B lymphocytes express lymphocyte function-associated antigen 1 (LFA-1 [CD11a/18]), very late antigen 4 (VLA-4 [CD49d], and CD44. Furthermore, we established that both the LFA-1/ICAM-1 and VLA-4/VCAM-1 adhesion pathways are involved in FDC-B lymphocyte binding, and therefore, these pathways might be essential in affinity selection of B cells and in the formation of B memory cells.
展开
DOI：
doi:10.1084/jem.173.6.1297
被引量：
Semantic Scholar
(全网免费下载)
掌桥科研
万方医学
Semantic Scholar
dx.doi.org
查看更多
NCBI
(全网免费下载)
NCBI
NCBI
Europe PMC
(全网免费下载)
Europe PMC
ResearchGate
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
学术范
(全网免费下载)
jvi.asm.org
jem.rupress.org
(全网免费下载)
钛学术
jcs.biologists.org
jem.rupress.org
jacionline.org
emboj.embopress.org
rupress.org
bloodjournal.org
SAGE
jleukbio.org
deepdyve.com
science-open.com
biomedsearch.com
(全网免费下载)
jimmunol.org
钛学术
(全网免费下载)
学术范
www.socolar.com
Semantic Scholar
(全网免费下载)
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
biomedsearch.com
(全网免费下载)
jem.rupress.org
(全网免费下载)
学术范
(全网免费下载)
钛学术
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
