Toll-like receptor signalling.

来自 EBSCO

阅读量:

835

作者:

S AkiraK Takeda

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摘要:

One of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms is through the Toll-like receptors (TLRs), which recognize specific molecular patterns that are present in microbial components. Stimulation of different TLRs induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also instructs the development of antigen-specific acquired immunity. Here, we review the rapid progress that has recently improved our understanding of the molecular mechanisms that mediate TLR signalling.

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关键词:

Immune response

DOI:

10.1038/nri1391

被引量:

1.3万

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引用走势

2010
被引量:1164

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