Slow wave sleep and a state resembling absence epilepsy induced in the rat by gamma-hydroxybutyrate.

阅读量:

55

作者:

M GodschalkMR DzoljicIL Bonta

展开

摘要:

The effect of γ-hydroxybutyrate (GHB) in relatively low doses (12.5–200 mg/kg) on sleep stages, electrocorticogram (ECoG) patterns and behavior was investigated in the rat. 50–100 mg/kg GHB induced slow wave sleep but, in contrast to the cat, not paradoxical sleep. 200 mg/kg induced a hypersynchronous, bilaterally symmetrical ECoG pattern, which was different in amplitude and frequency distribution from normally occuring high amplitude patterns. When the hypersynchrony occured in bursts, the rats displayed a sudden arrest of motor behavior. Convulsions were not induced. The results, together with the finding of others that GHB is a natural constituent of mammalian brain and our previous observation that the GHB-induced hypersynchrony can be antagonized by anti-absence (anti-petit mal) drugs are discussed in view of the possibility that GHB might play a role in the etiology of absence epilepsy in man.

展开

DOI:

10.1016/0014-2999(77)90096-6

被引量:

168

年份:

1977

通过文献互助平台发起求助,成功后即可免费获取论文全文。

相似文献

参考文献

引证文献

来源期刊

引用走势

2010
被引量:16

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用