Slow wave sleep and a state resembling absence epilepsy induced in the rat by gamma-hydroxybutyrate.

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摘要：

The effect of γ-hydroxybutyrate (GHB) in relatively low doses (12.5–200 mg/kg) on sleep stages, electrocorticogram (ECoG) patterns and behavior was investigated in the rat. 50–100 mg/kg GHB induced slow wave sleep but, in contrast to the cat, not paradoxical sleep. 200 mg/kg induced a hypersynchronous, bilaterally symmetrical ECoG pattern, which was different in amplitude and frequency distribution from normally occuring high amplitude patterns. When the hypersynchrony occured in bursts, the rats displayed a sudden arrest of motor behavior. Convulsions were not induced. The results, together with the finding of others that GHB is a natural constituent of mammalian brain and our previous observation that the GHB-induced hypersynchrony can be antagonized by anti-absence (anti-petit mal) drugs are discussed in view of the possibility that GHB might play a role in the etiology of absence epilepsy in man.

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关键词：

γ-Hydroxybutyrate Slow wave sleep Epilepsy, absence EEG hypersynchrony

DOI：

10.1016/0014-2999(77)90096-6

被引量：

168

年份：

1977