Vaccination with the extracellular domain of p185neu prevents mammary tumor development in neu transgenic mice

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作者：

LJ Esserman，T Lopez，R Montes，LN Bald，BM Fendly，MJ Campbell

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摘要：

The HER2/ neu oncogene product, p185 HER2/ neu , is overexpressed on the surface of many human breast cancers. Strains of transgenic mice have been developed that express the rat neu oncogene in mammary epithelial cells and develop spontaneous mammary tumors that overexpress p185 neu . This model provides an ideal system for testing interventions to prevent tumor development. In this study, we immunized neu -transgenic mice with a vaccine consisting of the extracellular domain of p185 neu (NeuECD). Immunized mice developed Neu-specific humoral immune responses, as measured by circulating anti-Neu antibodies in their sera, and cellular immune responses, as measured by lymphocyte proliferation to NeuECD in vitro. In addition, the subsequent development of mammary tumors was significantly lower in immunized mice than in controls and vaccine treatment was associated with a significant increase in median survival.

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关键词：

Key words Breast cancer vaccine HER2/neu Tumor immunotherapy Transgenic mice

DOI：

10.1007/s002620050539

被引量：

303

年份：

1999