Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors
摘要：
The essential transition metal ions are avidly accumulated by cells, yet they have two faces: They are put to use as required cofactors, but they also can catalyze cytotoxic reactions. Several families of proteins are emerging that control the activity of intracellular metal ions and help confine them to vital roles. These include integral transmembrane transporters, metalloregulatory sensors, and diffusible cytoplasmic metallochaperone proteins that protect and guide metal ions to targets. It is becoming clear that many of these proteins use atypical coordination chemistry to accomplish their unique goals. The different coordination numbers, types of coordinating residues, and solvent accessibilities of these sites are providing insight into the inorganic chemistry of the cytoplasm.
展开
关键词：
P-type atpase Copper-transporting atpase Cytochrome-c maturation Urease active-site Escherichia-coli Terminal domain Saccharomyces-cerevisiae Superoxide-dismutase Crystal-structure Menkes-disease
DOI：
10.1126/science.1085049
被引量：
年份：
2003
doi.org
万方医学
Semantic Scholar
(全网免费下载)
Semantic Scholar
掌桥科研
查看更多
dx.doi.org
Europe PMC
NCBI
Oxford Univ Press
JSTOR
NCBI
NRC Research Press
JBC
adsabs.harvard.edu
dialnet.unirioja.es
ResearchGate
(全网免费下载)
ProQuest
ResearchGate
EBSCO
EBSCO
Citeseer
(全网免费下载)
Citeseer
g3journal.org
biochemj.org
pubfacts.com
scienceopen.com
scindeks.ceon.rs
mendeley.com
钛学术
jcs.biologists.org
jb.asm.org
钛学术
(全网免费下载)
deepdyve.com
highbeam.com
scholars.northwestern.edu
go.galegroup.com
www.socolar.com
fasebj.org
jn.physiology.org
plantphysiol.org
mic.sgmjournals.org
jpet.aspetjournals.org
sciencemag.org
science-open.com
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
