Atomic structure and chemistry of human serum albumin

来自 NCBI

阅读量:

488

作者:

X.M. HeD.C. Carter

展开

摘要:

The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin.

展开

DOI:

10.1038/364362b0

被引量:

5232

年份:

1993

相似文献

参考文献

引证文献

来源期刊

Nature
1993/07/22

引用走势

2010
被引量:499

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用