Atomic structure and chemistry of human serum albumin
摘要：
The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin.
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关键词：
Amino Acid Sequence Computer Graphics Disulfides Humans Ligands Protein Conformation Serum Albumin X-Ray Diffraction
DOI：
10.1038/364362b0
被引量：
年份：
1993
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万方医学
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