Chromatin as a target antigen in human and murine lupus nephritis
摘要：
The present review focuses on pathogenic molecular and transcriptional events in patients with lupus nephritis. These factors are renal DNaseI, exposed chromatin fragments and the corresponding chromatin-reactive autoantibodies. Lupus nephritis is the most serious complication in human systemic lupus erythematosus, and is characterised by deposition of chromatin fragment-IgG complexes in the mesangial matrix and glomerular basement membranes. The latter deposition defines end-stage disease. This event is stringently linked to a renal-restricted shutdown of expression of the DNaseI gene, as determined by loss of DNaseI mRNA level and DNaseI enzyme activity. The major aim of the present review is to generate new therapeutic strategies based on new insight into the disease pathogenesis.
展开
关键词：
Infection rate rituximab infliximab etanercept adalimumab systemic lupus erythematosus Sjogren syndrome vasculitis
DOI：
10.1186/ar3281
被引量：
年份：
2011
Springer
Springer
(全网免费下载)
国家科技图书文献中心
(权威机构)
EBSCO
万方医学
查看更多
掌桥科研
dx.doi.org
NCBI
NCBI
BioMed Central
Europe PMC
OALib
ResearchGate
ProQuest
EBSCO
readcube.com
deepdyve.com
mailer.oalib.net
paperity.org
core.ac.uk
arthritis-research.com
pubget.com
mendeley.com
biomedsearch.com
bvsalud.org
scienceopen.com
symedicine.org
onAcademic
BioMed Central
(全网免费下载)
Springer
(全网免费下载)
BioMed Central
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
