A Role for the Phagosome in Cytokine Secretion
摘要：
Membrane traffic in activated macrophages is required for two critical events in innate immunity: proinflammatory cytokine secretion and phagocytosis of pathogens. We found a joint trafficking pathway linking both actions, which may economize membrane transport and augment the immune response. Tumor necrosis factor α (TNFα) is trafficked from the Golgi to the recycling endosome (RE), where vesicle-associated membrane protein 3 mediates its delivery to the cell surface at the site of phagocytic cup formation. Fusion of the RE at the cup simultaneously allows rapid release of TNFα and expands the membrane for phagocytosis.
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关键词：
TUMOR-NECROSIS-FACTOR FACTOR-ALPHA RECYCLING ENDOSOMES PLASMA-MEMBRANE MACROPHAGES PHAGOCYTOSIS GOLGI CELLS EXOCYTOSIS TRANSPORT
DOI：
10.1126/science.1120225
被引量：
年份：
2005
掌桥科研
万方医学
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