A general solution for unstable boronic acids: slow-release cross-coupling from air-stable MIDA boronates.
摘要：
Many boronic acids, including 2-heterocyclic, vinyl, and cyclopropyl derivatives, are inherently unstable, which can limit their benchtop storage and/or efficient cross-coupling. We herein report the first general solution to this problem: in situ slow release of unstable boronic acids from the corresponding air-stable MIDA boronates. This remarkably general approach has transformed all three classes of these unstable boronic acids into shelf-stable and highly effective building blocks for cross-coupling with a wide range of aryl and heteroaryl chlorides.
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关键词：
general (heterocyclic compounds C‐C bond formation alkenes (benzene compounds cycloalkylphenyl derivatives
DOI：
10.1002/chin.200941089
被引量：
年份：
2009
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