MFR, a Putative Receptor Mediating the Fusion of Macrophages

来自 Semantic Scholar

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作者：

C Saginario，H Sterling，C Beckers，R Kobayashi，M Solimena，E Ullu，A Vignery

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摘要：

We had previously identified a macrophage surface protein whose expression is highly induced, transient, and specific, as it is restricted to actively fusing macrophages in vitro and in vivo. This protein is recognized by monoclonal antibodies that block macrophage fusion. We have now purified this protein and cloned its corresponding cDNA. This protein belongs to the superfamily of immunoglobulins and is similar to immune antigen receptors such as the T-cell receptor, B-cell receptor, and viral receptors such as CD4. We have therefore named this protein macrophage fusion receptor (MFR). We show that the extracellular domain of MFR prevents fusion of macrophages in vitro and therefore propose that MFR belongs to the fusion machinery of macrophages. MFR is identical to SHPS-1 and BIT and is a homologue of P84, SIRPalpha, and MyD-1, all of which have been recently cloned and implicated in cell signaling and cell-cell interaction events.

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关键词：

Cell Fusion Macrophages, Alveolar Membrane Glycoproteins Nerve Tissue Proteins 细胞融合巨噬细胞, 肺泡膜糖蛋白类神经组织蛋白质类受体, 细胞表面