Regulation of cell death: the calcium-apoptosis link.
摘要：
To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living organisms--survival factor or ruthless killer. It has long been known that Ca2+ signals govern a host of vital cell functions and so are necessary for cell survival. However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death.
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关键词：
Mitochondria Animals Humans Necrosis Calcium Signal Transduction Apoptosis Calcium Signaling Enzyme Activation Homeostasis
DOI：
10.1038/nrm1150
被引量：
年份：
2003
Taylor & Francis
Nature
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万方医学
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