Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study.

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135

作者：

Albert Hofman and Alewijn Ott and Monique MB Breteler and Michiel L Bots and Arjen JC Slooter and Frans van Harskamp and Cornelia N van Duijn and Christine Van Broeckhoven and Diederick E Grobbee

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摘要：

BACKGROUND: have been implicated in , but whether is related to the most frequent type of , , is not known. The genotype has been associated with , and we postulate that it plays a part, together with , in the aetiology of . We investigated the frequency of and its subtypes in relation to and .: We did a population-based study of 284 patients with , 207 of whom had , and 1698 individuals who were not . Indicators of included vessel wall thickness and plaques of the carotid arteries, assessed by ultrasonography, and the ratio of ankle-to-brachial systolic blood pressure as a measure of . Based on these indicators participants were scored from 0 (no ) to 3 (severe ) for degree of . polymorphisms were assessed in 246 patients and in 928 controls.: All indicators of were associated with (odds ratios ranging from 1.3 to 1.9) and its major subtypes (odds ratios 1.3-1.8) and (odds ratios 1.9-3.2). The frequencies of all . , and increased with the degree of . The odds ratio for in those with severe compared with those without was 3.0 (95% CI 1.5-6.0; p = 0.001). In participants with the 4 genotype and an score of 2 or 3 the odds ratio for all was 4.5 (2.0-10.1; p < 0.001), for was 3.9 (1.6-9.6; p = 0.002), and for was 19.8 (4.1-95.0; p < 0.001).: These findings suggest that and its two major subtypes and are associated with and that there is an interaction between and in the aetiology of .

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关键词：

Humans Arteriosclerosis Dementia, Vascular Dementia Alzheimer Disease Apolipoproteins E Prevalence Genotype Aged Aged, 80 and over