Diffuse large B-cell lymphoma primary of lung

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摘要：

Primary lung lymphoma (PLL) and diffuse large Bcell lymphoma (DLBCL) is a rare entity and the biological features, clinical presentation, prognosis markers and treatment have not been well defined. We present 82 cases of PLLDLBCL in a uniform population and treated with conventional chemotherapy: CHOP (cyclophosphamide, doxorubicin vincristine and prednisone). To the best of our knowledge, this is the largest series with long term follow reported. We also performed immunohistochemical studies to determine if the cell of origin [germinal center (GC) and nonGC] have a prognostic significance. All patients were at an early stage and lowclinical risk without bulk disease and normal levels of lactic dehydrogenase and beta 2 microglobulin. Complete response was achieved in 77 cases (94%), actuarial curves at 10 years showed that eventfree survival (EFS) was 90% and overall survival was 92%. Fiftynine patients were of GC phenotype and 23 of nonGC phenotype. Complete response (93% versus 91%), EFS (91% versus 80%) and overall survival (89% versus 78%) respectively, were not statistically different. Treatment was well tolerated, and second late events have not been seen. We conclude that PLLDLBCL is an extranodal lymphoma with a good prognosis event in patients of nonGC phenotype.

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关键词：

Malignant lymphoma Lung lymphoma Immunohistochemistry Prognostic factors

DOI：

10.1179/102453311X12940641877722

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年份：

2011