登录注册
高级搜索
包含全部检索词
包含精确检索词
包含至少一个检索词
不包含检索词
出现检索词的位置
文章任何位置
位于文章标题
作者
机构
出版物 期刊
会议
发表时间  - 
语言检索范围 不限
不限 英文 中文
文献
期刊
学者
论文查重 优惠
论文查重
开题分析
单篇购买
文献互助

Lin28 promotes transformation and is associated with advanced human malignancies

来自 EBSCO

阅读量：

94

作者：

SR Viswanathan，JT Powers，W Einhorn，Y Hoshida，TL Ng，S Toffanin，M O'Sullivan，J Lu，LA Phillips，VL Lockhart

展开

摘要：

Multiple members of the let-7 family of miRNAs are often repressed in human cancers, thereby promoting oncogenesis by derepressing targets such as HMGA2, K-Ras and c-Myc. However, the mechanism by which let-7 miRNAs are coordinately repressed is unclear. The RNA-binding proteins LIN28 and LIN28B block let-7 precursors from being processed to mature miRNAs, suggesting that their overexpression might promote malignancy through repression of let-7. Here we show that LIN28 and LIN28B are overexpressed in primary human tumors and human cancer cell lines (overall frequency approximately 15%), and that overexpression is linked to repression of let-7 family miRNAs and derepression of let-7 targets. LIN28 and LIN28b facilitate cellular transformation in vitro, and overexpression is associated with advanced disease across multiple tumor types. Our work provides a mechanism for the coordinate repression of let-7 miRNAs observed in a subset of human cancers, and associates activation of LIN28 and LIN28B with poor clinical prognosis.

展开

关键词：

Animals Carcinoma, Hepatocellular Cell Line, Tumor Cell Transformation, Neoplastic DNA-Binding Proteins Gene Expression Regulation, Neoplastic Humans Liver Neoplasms Mice MicroRNAs

DOI：

10.1038/ng.392

被引量：

1583

收藏 引用 批量引用 分享
全部来源 免费下载 求助全文 全文购买

通过文献互助平台发起求助，成功后即可免费获取论文全文。

我们已与文献出版商建立了直接购买合作。

你可以通过身份认证进行实名认证，认证成功后本次下载的费用将由您所在的图书馆支付

您可以直接购买此文献，1~5分钟即可下载全文，部分资源由于网络原因可能需要更长时间，请您耐心等待哦~

身份认证 全文购买

相似文献

参考文献

引证文献

来源期刊

Nature Genetics

研究点推荐

引用走势

2013
被引量：174

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用！

引用