SOME NARCOTIC ANTAGONISTS IN THE BENZOMORPHAN SERIES.
摘要：
The behavioral, respiratory and cardiovascular effects of four analgesic antagonists derived from the benzomorphan nucleus have been described. In addition, the ability of these agents to reverse the respiratory, cardiovascular and behavioral depression produced by morphine and meperidine has been reported.Two of the compounds, 2-allyl-5-ethyl-2′-hydroxy-9-methyl-6,7-benzomorphan (I) and 2-cyclopropylmethyl-2′-hydroxy-5,9-dimethyl-6,7-benzomorphan (IV) proved to be potent antagonists.The other two, 2-(3,3-dimethylallyl)-2′-hydroxy-5,9-dimethyl-6,7-benzomorphan (II) and 2-(3,3-dimethylallyl)-5-ethyl-2′-hydroxy-9-methyl-6,7-benzomorphan (III), were found to be weak antagonists.
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关键词：
Cats Haplorhini Mice Rats Heterocyclic Compounds Meperidine Pentazocine Phenazocine Morphine Nalorphine
DOI：
10.1007/BF00246889
被引量：
年份：
1964
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