Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression
摘要：
Regulatory influence of the G-quadruplex or G4 motif present within the nuclease hypersensitive element (NHE) in the promoter ofc-MYChas been noted. On the other hand, association of NM23-H2 to the NHE leads toc-MYCactivation. Therefore, NM23-H2 interaction with the G4 motif within thec-MYCNHE presents an interesting mechanistic possibility. Herein, using luciferase reporter assay and chromatin immunoprecipitation we show NM23-H2 mediatedc-MYCactivation involves NM23-H2-G4 motif binding within thec-MYCNHE. G4 motif complex formation with recombinant NM23-H2 was independently confirmed using fluorescence energy transfer, which also indicated that the G4 motif was resolved to an unfolded state within the protein-bound complex. Taken together, this supports transcriptional role of NM23-H2 via a G4 motif.
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DOI：
10.1093/nar/gkn919
被引量：
年份：
2009
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