Design and formulation of nano-porous controlled porosity osmotic pumps (CPOPs) containing a poorly water soluble drug, glibenclamide
摘要：
The aim of this study was to design and develop controlled porosity osmotic pumps containing glibenclamide (as an insoluble agent) coated with nano-scale pore formers. Solubility enhancement methods including co-grinding with an anionic surfactant and pH adjustment in core formulation were employed and the prepared cores were coated with nano-suspension coating method. The prepared nano-porous osmotic pump (CPOP) system assessed by comparative parameters including D<sub>24h</sub> (cumulative release percentage after 24h), tL (lag time of the drug release from device), drug release rate from device and RSQ<sub>zero</sub>. Solubility studies of glibenclamide co-ground with an anionic surfactant showed that by increasing the concentration of SLS to 83.33% (ratio of drug: SLS 1:5) in the presence of calcium carbonate, the solubility of glibenclamide was enhanced remarkably. Release study also displayed enhanced D24h and improved kinetic related parameter (RSQ <sub>zero</sub>) by increasing SLS and calcium carbonate in the core formulation via nano-porous CPOPs. It can be concluded that by employing both co-grinding technology and pH adjustment method in core formulation of glibenclamidenano-suspension coated CPOPs, enhanced D<sub>24h,</sub> drug release rate and improved kinetic related parameter (RSQ <sub>zero</sub>)) was achieved.
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年份：
2019
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