摘要：

Targeting protein-protein interactions by small molecule compounds is challenging; however, exciting achievements have been made over the past decade. New targets of PPIs were identified, and lots of small molecule modulators were developed. In this chapter, we make a brief review of the research into PPIs and their small molecule inhibitors. We focus on the progress in some new targets of PPIs involving in biological processes such as epigenetic modification, ubiquitin-mediated protein degradation, immune response, RTK signaling pathway, and copper transport. These case studies may provide researchers with a basic overview of this area. Several other promising targets are also discussed herein.

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