BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE

阅读量:

21

申请(专利)号:

CA20082683948

申请日期:

2008-04-17

公开/公告号:

CA2683948A1

公开/公告日期:

2008-10-30

申请(专利权)人:

MERCK FROSST CANADA LTD.

被引量:

2

摘要:

Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis.

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