The physiology of brain histamine.

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作者：

RE Brown，DR Stevens，HL Haas

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摘要：

Histamine-releasing neurons are located exclusively in the TM of the hypothalamus, from where they project to practically all brain regions, with ventral areas (hypothalamus, basal forebrain, amygdala) receiving a particularly strong innervation. The intrinsic electrophysiological properties of TM neurons (slow spontaneous firing, broad action potentials, deep afterhyperpolarisations, etc.) are extremely similar to other aminergic neurons. Their firing rate varies across the sleep-wake cycle, being highest during waking and lowest during rapid-eye movement sleep. In contrast to other aminergic neurons somatodendritic autoreceptors (H

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关键词：

AA, arachidonic acid ACTH, adrenocorticotrophic hormone &alpha -FMH, &alpha -fluoromethylhistidine &alpha -MSH, &alpha -melanocyte stimulating hormone AMPA, &alpha -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid cAMP, cyclic adenosine 3&prime , 5&prime monophosphate cGMP, cyclic guanosine 3&prime , 5&prime monophosphate CRF, corticotropin releasing factor CSF, cerebrospinal fluid CREB, cAMP-response element binding protein DAG, diacylglycerol DAP, depolarizing afterpotential EEG, electroencephalogram EPSC, excitatory postsynaptic current GABA, &gamma -aminobutyric acid GH, growth hormone HDC, <scp>l</scp>-histidine decarboxylase HNMT, histamine N-methyl transferase icv, intracerebroventricular IP<inf>3</inf>, inositol triphosphate IPSP, inhibitory postsynaptic potential LGN, lateral geniculate nucleus LTP, long-term potentiation MAO, monoamine oxidase MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine NMDA, N-methyl-<scp>d</scp>-aspartate NO, nitric oxide PKA, protein kinase A PKC, protein kinase C POM