Generation of memory B cells and plasma cells in vitro
摘要：
After germinal center B cells undergo somatic mutation and antigen selection, they become either memory B cells or plasma cells, but the signal requirements that control entry into either pathway have been unclear. When purified human germinal center cells were cultured with interleukin-2, interleukin-10, and cells expressing CD40 ligand, cells with characteristics of memory B cells were generated. Removal of CD40 ligand from the system resulted in terminal differentiation of germinal center B cells into cells with the characteristics of plasma cells. These results indicate that CD40 ligand directs the differentiation of germinal center B cells toward memory B cells rather than toward plasma cells.
展开
DOI：
10.1126/science.7537388
被引量：
年份：
1995
Taylor & Francis
Semantic Scholar
掌桥科研
万方医学
dx.doi.org
查看更多
Europe PMC
NCBI
NCBI
JSTOR
AACR
adsabs.harvard.edu
ProQuest
ResearchGate
ResearchGate
(全网免费下载)
EBSCO
mendeley.com
jimmunol.org
jleukbio.org
jvi.asm.org
www.socolar.com
sciencemag.org
SAGE
highbeam.com
cheric.org
jacionline.org
bloodjournal.org
go.galegroup.com
ar.newsmth.net
(全网免费下载)
jem.rupress.org
ganino.com
(全网免费下载)
onAcademic
hal.archives-ouvertes.fr
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
