Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG.
摘要：
Subpopulations of thymus-derived T lymphocytes bearing receptors for either IgM or IgG molecules were isolated from human peripheral blood. Those with receptors for IgM (T.M) provided help in a cell dose-dependent fashion for the pokeweed mitogen-induced differentiation of B lymphocytes in vitro, whereas cells with receptors for IgG (T.G) did not. T.G cells, on the hand, efficiently suppressed the differentiation and proliferation of B cells in the pokeweed system in the presence of helper T.M cells. This suppressive activity of T.G cells required prior interaction of the T.G cells with immune complexes. The helper activity of T.M cells was relatively radioresistant while the suppressor activity of T.G cells was radiosensitive. The results indicate that helper and suppressor functions of human T lymphocytes in this model system are mediated by different subpopulations of T cells which can be distinguished by their ability to bind IgM or IgG immune complexes, respectively.
展开
DOI：
10.1084/jem.146.1.184
被引量：
年份：
1977
Semantic Scholar
掌桥科研
万方医学
Semantic Scholar
(全网免费下载)
dx.doi.org
查看更多
Europe PMC
(全网免费下载)
NCBI
Oxford Univ Press
Europe PMC
NCBI
NCBI
(全网免费下载)
JBC
ResearchGate
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
Citeseer
rupress.org
biomedsearch.com
(全网免费下载)
mysciencework.com
jem.rupress.org
jimmunol.org
cghjournal.org
deepdyve.com
jacionline.org
moh-it.pure.elsevier.com
nejm.org
mendeley.com
jem.rupress.org
(全网免费下载)
onAcademic
www.socolar.com
钛学术
钛学术
(全网免费下载)
Semantic Scholar
(全网免费下载)
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
jem.rupress.org
(全网免费下载)
biomedsearch.com
(全网免费下载)
钛学术
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
