uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180
阅读量：
26
摘要：
The urokinase-type plasminogen activator receptor (uPAR) drives tumor cell membrane protrusion and motility through activation of Rac; however, the pathway leading from uPAR to Rac activation has not been described. In this study we identify DOCK180 as the guanine nucleotide exchange factor acting downstream of uPAR. We show that uPAR cooperates with integrin complexes containing β integrin to drive formation of the p130Cas-Crkll signaling complex and activation of Rac, resulting in a Rac-driven elongated-mesenchymal morphology, cell motility, and invasion. Our findings identify a signaling pathway underlying the morphological changes and increased cell motility associated with uPAR expression.
展开
关键词：
Cell Line, Tumor Cell Surface Extensions Crk-Associated Substrate Protein 酶激活 肿瘤侵润 磷酰化 磷酸酪氨酸 蛋白质结构, 三级 受体, 细胞表面
DOI：
10.1083/jcb.200712050
被引量：
年份：
2008
国家科技图书文献中心
(权威机构)
万方医学
dx.doi.org
NCBI
Europe PMC
查看更多
JSTOR
Europe PMC
(全网免费下载)
NCBI
AACR
JBC
AGRIS
ResearchGate
ProQuest
ResearchGate
(全网免费下载)
Citeseer
EBSCO
readcube.com
core.ac.uk
idi.ntnu.no
pubget.com
pubfacts.com
bloodjournal.org
rupress.org
jcs.biologists.org
jimmunol.org
jcb.rupress.org
scienceopen.com
biochemj.org
molbiolcell.org
embojnl.embopress.org
ukpmc.ac.uk
deepdyve.com
www.socolar.com
学术范
mendeley.com
onAcademic
jcb.rupress.org
(全网免费下载)
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
