Comparison of the anaesthetic and haemodynamic effects of chlormethiazole and thiopentone
摘要：
Two groups of eight women (60 – 85 yr) undergoing gynaecological operations of 50 to 130 min duration were compared. Anaesthesia was induced with either thiopentone (mean 4.5mg kg) or chlormethiazole(mean 6.0 ing kg) and maintained with nitrous oxide and pethidine in combination with the drug used for the induction. The hourly maintenance dose and the plasma concentration determined at equilibrium were greater for chlormethiazole (means 4.7mg kghand 27(μmol litre) compared with 1.3 mgkgh(P< 0.01) and 16μmol litrerespectively for thiopentone (P< 0.02). Impedance cardiography showed that cardiac output was decreased by 30–40% in the thiopentone group (P < 0.01), whereas ho significant change was observed in the chlormethiazole group. Chlormethiazole anaesthesia was followed by a significant increase (P<0.02) in stroke volume. No correlations were found between the plasma concentrations and changes in the haemodynamic indices for either of the drugs.
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DOI：
10.1093/bja/55.5.391
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