Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase
摘要：
IN the yeast Saccharomyces cerevisiae a number of mutants potentially defective in DNA replication have been isolated 1–3 . However, the only defective gene product so far identified in any of these mutants is that in cdc 21 which is defective in thymidylate synthetase 4,5 . We report here that cdc 9–l, isolated by Hartwell as a conditional cell cycle mutant 6 , is defective in a DNA ligase involved in both replication and repair of DNA. A mutant with similar properties has recently been described in Schizosaccharomyces pombe 7 .
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关键词：
Saccharomyces cerevisiae DNA Ligases Polynucleotide Ligases Cell Cycle DNA Repair DNA Replication Phenotype Mutation
DOI：
10.1038/274891a0
被引量：
年份：
1978
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