Adhesion of mouse fibroblasts on hexamethyldisiloxane surfaces with wide range of wettability

来自 Wiley

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作者：

J Wei，M Yoshinari，S Takemoto，M Hattori，E Kawada，B Liu，Y Oda

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摘要：

Surface wettability is an important physicochemical property of biomaterials, and it would be more helpful for understanding this property if a wide range of wettability are employed. This study focused on the effect of surface wettability on fibroblast adhesion over a wide range of wettability using a single material without changing surface topography. Plasma polymerization with hexamethyldisiloxane followed by oxygen (O2)-plasma treatment was employed to modify the surfaces. The water contact angle of sample surfaces varied from 106° (hydrophobicity) to almost 0° (super-hydrophilicity). O2 functional groups were introduced on polymer surfaces during O2-plasma treatment. The cell attachment study confirmed that the more hydrophilic the surface, the more fibroblasts adhered in the initial stage that includes super-hydrophilic surfaces. Cells spread much more widely on the hydrophilic surfaces than on the hydrophobic surfaces. There was no signi

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关键词：

cell adhesion fibroblasts glow discharge (RF/Plasma) hydrophilic surface modification

DOI：

10.1002/jbm.b.30638

被引量：

186

年份：

2007