Nine-step enantioselective total synthesis of (+)-minfiensine.
摘要：
MacMillan and co-workers report an expedient enantioselective total synthesis of (+)-minfiensine, employing an organocatalytic cascade in the key step. Vinyl indole 2 prepared in three steps from a commercially available precursor 1 underwent an organocatalytic Diels-Alder cycloaddition with propynal, followed by isomerization and amine cyclization. In situ reduction furnished pyrroloindoline 4 in excellent yield and enantioselectivity. This intermediate was elaborated to (+)-minfiensine in five more steps via a radical cyclization ( 5 6 ).
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DOI：
10.1055/s-0029-1218111
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年份：
2009
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