Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
摘要：
The influence of acidosis on the expression of the vascular endothelial growth factor (VEGF) gene was determined. FG human pancreatic adenocarcinoma cells were incubated for various time periods in media at a physiologically relevant pH level (6.7–7.4). The expression of VEGF mRNA and protein secretion was inversely correlated with pH in a pH- and time-dependent manner. Transient acidosis also activated the VEGF promoter/enhancer luciferase reporter, which was consistent with an increased VEGF gene transcription rate and VEGF mRNA half-life. These data indicated that acidosis transcriptionally and posttranscriptionally regulates VEGF expression, suggesting that an acidic tumor microenvironment contributes to tumor angiogenesis and progression.
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关键词：
ONC oncogenes cancer apoptosis tumor suppressor genes tumor viruses molecular oncology cell cycle growth factors growth factor receptors
DOI：
10.1038/sj.onc.1204500
被引量：
年份：
2001
Taylor & Francis
Nature
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