Cutting Edge: Control of CD8~+ T Cell Activation by CD4~+CD25~+ Immunoregulatory Cells
摘要：
CD4~+CD25~+ regulatory T cells inhibit organ-specific autoim- mune diseases induced by CD4~+CD25~- T cells and are potent suppressors of CD4~+CD25~- T cell activation in vitro. We dem- onstrate that CD4+CD25~+ T cells also suppress both prolifer- ation and IFN-#gamma# production by CD8~+ T cells induced either by polyclonal or Ag-specific stimuli. CD4~+CD25~+ T cells inhibit the activation of CD8~+ responders by inhibiting both IL-2 pro- duction and up-regulation ofIL-2R#alpha#-chain (CD25) expression. Suppression is mediated via a T-T interaction as activated CD4~+CD25~+ T cells suppress the responses ofTCR-transgenic CD8~+ T cells stimulated with soluble peptide-MHC class I tetramers in the complete absence of A PC. These results broaden the immunoregulatory role played by CD4~+CD25~+ T cells in the prevention of autoimmune diseases, but also raise the pos- sibility that they may hinder the induction of effector CD8~+ T cells to tumor or foreign Ags.
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关键词：
Animals Mice, Inbred BALB C Mice, Inbred C57BL Mice T-Lymphocyte Subsets CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cells, Cultured Receptors, Antigen, T-Cell Receptors, Interleukin-2
DOI：
10.1039/pc093333
被引量：
年份：
2001
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