Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.
摘要：
apoE-deficient mice have been created by homologous recombination in ES cells. On a low fat, low cholesterol chow diet these animals have plasma cholesterol levels of 494 mg/dl compared with 60 mg/dl in control animals, and when challenged with a high fat Western-type diet, these animals have plasma cholesterol levels of 1821 mg/dl compared with 132 mg/dl in controls. This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and coronary and pulmonary arteries. apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
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关键词：
Aorta Coronary Vessels Pulmonary Artery Stem Cells Animals Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Mice Arteriosclerosis
DOI：
10.1016/0092-8674(92)90362-G
被引量：
年份：
1992
Elsevier
Taylor & Francis
Wiley
万方医学
dx.doi.org
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