Propargyl nitroxides and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders
申请(专利)号:
11/191212
申请日期:
07/26/2005
公开/公告号:
US20060025446
公开/公告日期:
02/02/2006
被引量:
摘要:
Disclosed are compounds having the structure: wherein Z is —OH or —O; and A is: wherein X and Y are independently NR 1 or O, where R 1 is H or C 1 -C 4 alkyl; and R 2 is H, C 1 -C 4 alkyl or t-butoxycarbonyl, wherein W is C 3 -C 4 alkynyl; and R 1 is H or C 1 -C 4 alkyl, or wherein R 1 is H, C 1 -C 4 alkyl, or C 3 -C 4 alkynyl; and R 3 is H, OH, O(C 1 -C 4 alkyl), or a halogen, optically active enantiomers, pharmaceutically acceptable salts of the compounds, pharmaceutical compositions containing such compounds or salts, and processes for their preparation. The subject invention also provides methods of alleviating symptoms of neurologic, autoimmune, and inflammatory disorders caused by the presence of reactive oxygen species, methods of preventing oxidation of lipids, proteins, or deoxyribonucleic acids on a cellular level, and methods of protecting human red blood cells from lysis by O 2 radicals.
展开
通过文献互助平台发起求助,成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用!