Evaluation of factors related to late recurrence--later than 10 years after the initial treatment--in primary breast cancer.

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238

作者：

R Nishimura，T Osako，Y Nishiyama，R Tashima，M Nakano，M Fujisue，Y Toyozumi，N Arima

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摘要：

Background: Breast cancer is associated with a relatively good prognosis. Prognostic factors examined to date are related to early recurrence while those related to late recurrence and their countermeasures remain unclear. Therefore, we examined the factors related to late recurrence. Patients and Methods: From January 1980 to August 2012, 4,774 patients who underwent primary treatment and estrogen (ER) and progesterone receptor (PgR) assessment were enrolled in this study. The patients were divided into two groups, those with a follow-up period = 10 years. Results:The overall 10-year cumulative disease-free survival rate was 79.5%, and the recurrence rate at >= 10 years was 5.8%. A multivariate analysis revealed that the factors related to late recurrence were PgR positivity and positive nodes. This result differed from that for early recurrence in terms of ER/PgR, Ki-67 index and p53 overexpression. Conclusion: PgR positivity and lymph node metastases significantly correlated with late recurrence. Therefore, it is important to evaluate appropriate measures such as treatment period and treatment regimen for hormone-sensitive patients. Copyright (C) 2013 S. Karger AG, Basel

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关键词：

Breast cancer Estrogen receptor Ki-67 Late recurrence Progesterone receptor

DOI：

10.1159/000353099

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年份：

2013